The Actos class action lawsuit investigation does not dispute the claims by Takeda Pharmaceuticals that Actos can help treat type-2 diabetes. Actos lawyers and Actos bladder cancer attorneys are investigating claims that long-term treatment with Actos may cause cancerous tumors in the bladder as a side effect of using Actos.
A 10-year study showed that diabetics who took Actos (pioglitazone) for more than a year had not just a slightly elevated risk of cancerous bladder tumors, but, increased their risk of bladder cancer by 40%. Recently a lawsuit was filed by an Actos user who only used the type 2 diabetes treatment for four months before developing bladder tumors and being diagnosed with bladder cancer.Actos Heart Attacks, Heart Failure
Clinical trials and studies show a link between Actos and congestive heart failure. This risk of Actos heart failure is so significant that the medication now carries a black-box warning, as mandated by the FDA in 2007. The warning states that Actos may cause or exacerbate congestive heart failure in some patients. Patients taking Actos should be monitored “carefully” for signs and symptoms of heart failure, including excessive, rapid weight gain, dyspnea, and/or edema.One Actos heart failure study published in August 2010 in the American Heart Association journal found that patients taking Actos and Avandia were 4% more likely to experience heart attacks, heart failure, and die. Both medications belong to a class of drugs known as thiazolidinediones, which are designed to lower blood sugar levels by making tissues more sensitive to insulin. Thiazolidinediones have also been known to cause heart problems.
After the study concluded, researchers found that 602 patients who took Avandia and 599 patients who took Actos suffered either a heart attack, heart failure, or both, or died. There were 217 deaths in each group.
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